GSK3 beta Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1543
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GSK3 beta
Rabbit Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IF, IHC,
ICC, FC
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H, M
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46.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1,000-1:5,000
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-
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:100
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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GSK3 beta
Rabbit Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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2932(Human);
56637(Mouse)
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SwissProt
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P49841(Human);
Q9WV60(Mouse)
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Synonyms
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GSK3B;
Glycogen Synthase Kinase 3 Beta
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Category
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PI3K/Akt/mTOR
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Background
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Glycogen
synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase
involved in a diverse array of signaling pathways, including glycogen
synthesis and cellular adhesion, and has been implicated in Alzheimer's
disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular
localization. Tau, a microtubule-binding protein which serves to stabilize
microtubules in growing axons, is found to be hyper-phosphorylated in paired
helical filaments (PHF), the major fibrous component of neurofibrillary
lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is
thought to be the critical event leading to the assembly of PHF. Six Tau
protein isoforms have been identified, all of which are phosphorylated by
GSK-3. This presents the possibility that miscues in GSK-3 signaling
contribute to the onset of Alzheimer's disease.
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包装清单:
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产品编号
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产品名称
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包装
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XY1543
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GSK3 beta
Rabbit Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
GSK3 beta Rabbit
Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10