Collagen XVII Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1078
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Collagen XVII
Rabbit Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC
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H, M, R
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130/180 kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1000-1:2000
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:200
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-
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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Collagen XVII
Rabbit Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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1308(Human);
12821(Mouse)
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SwissProt
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Q9UMD9(Human);
Q07563(Mouse)
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Synonyms
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ERED; BP180;
BPA-2; BPAG2; LAD-1; BA16H23.2; COL17A1
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Category
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Cytoskeletal
Signaling
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Background
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The extensive
collagen family comprises several chain types, including fibril-forming
interstitial collagens and basement membrane collagens, with each type
containing multiple isoforms. Products of the COL gene family, collagens are
characterized as fibrous, extracellular matrix proteins with high tensile
strength that constitute the major components of connective tissues, such as
tendons and cartilage. All collagens contain a triple helix domain and
frequently show lateral self-association in order to form complex connective
tissues. Collagen Type XVII, also designated BP180, represents a type II
transmembrane, epithelial adhesion molecule that plays a role in cell
migration and differentiation. The full length Collagen Type XVII protein is
expressed in hemidesmosomes of keratinocytes. Proteolytic shedding of
Collagen Type XVII results in a species in the extracellular matrix, and this
process may be mediated by a disintegrin and metalloprotease (ADAM) family
member. The BPAG2 gene, which encodes the Collagen Type XVII protein, maps to
human chromosome 10q25.1. Mutations in this gene result in Bullous
pemphigoid, an inflammatory subepidermal blistering skin disease associated
with an IgG autoimmune response to Collagen Type XVII.
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包装清单:
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产品编号
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产品名称
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包装
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XY1078
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Collagen XVII
Rabbit Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
Collagen XVII
Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10