PBR Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1024
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PBR Rabbit
Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC, FC
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H, M
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18.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1000-1:5000
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:10-1:100
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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PBR Rabbit
Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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706(Human);
12257(Mouse)
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SwissProt
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P30536(Human);
P50637(Mouse)
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Synonyms
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DBI; IBP; MBR;
PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18
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Category
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Apoptosis;
Metabolism
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Background
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Mitochondrial
peripheral-type benzodiazepine receptor (PBR) is an indispensable element of
the steroidogenic machinery, where it mediates the delivery of cholesterol to
the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation.
PBR is composed of three subunits, an isoquinoline binding site, a
voltage-dependent anion channel and an adenine nucleotide carrier. PBR is
genetically conserved from bacteria to humans and in humans is widely
expressed in peripheral organs, whereas in the brain, it is sparse and
located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid
(PFDA) inhibits the Leydig cell steroidogenesis by XYfecting PBR mRNA
stability, thus inhibiting PBR expression, cholesterol transport into the
mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1
( peripheral benzodiazepine receptor-associated protein 1), is found to
specifically interact with PBR. The polypeptide diazepam binding inhibitor is
an endogenous PBR ligand. PBR also binds Ro 5-4864 (4' -chlorodiazepam) and
PK 11185 (an isoquinoline carboxamide derivative), but not clonazepam, and
PBR regulates the cholesterol transport that results in decreased circulating
corticosterone levels.
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包装清单:
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产品编号
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产品名称
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包装
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XY1024
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PBR Rabbit
Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
PBR Rabbit
Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10