CREB Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1018
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CREB Rabbit
Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC, FC
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H, M, R
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40.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1000-1:5000
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:10-1:100
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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CREB Rabbit
Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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1385(Human);
12912(Mouse); 81646(Rat)
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SwissProt
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P16220(Human);
Q01147(Mouse); P15337(Rat)
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Synonyms
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CREB; CREB-1
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Category
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Neuronal
Signaling
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Background
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Eukaryotic
gene transcription is regulated by sequence-specific transcription factors
that bind modular cis-acting promoter and enhancer elements. The ATF/CREB
transcription factor family binds the palindromic cAMP response element (CRE)
octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also
designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contains
highly divergent N-terminal domains, but shares a C-terminal leucine zipper
for dimerization and DNA binding. Although CREB can bind to DNA in an
unphosphorylated state, it cannot activate transcription. Phosphorylation of
CREB on Ser 133 by protein kinase A facilitates its interaction with the
CREB-binding protein (CBP) and activates the basal transcription complex.
CREB functions in neoglucogenesis through interactions with the nuclear
coactivator PGC-1. CREB may play a role in the pathogenesis of type II
diabetes and dilated cardiomyopathy.
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包装清单:
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产品编号
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产品名称
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包装
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XY1018
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CREB Rabbit
Monoclonal Antibody
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50μl
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AZ050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
CREB Rabbit
Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10