HER2/ErbB2 Rabbit Polyclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY0177
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HER2/ErbB2
Rabbit Polyclonal Antibody
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50μl
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416.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, ICC, IHC,
IF
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H
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140KDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:500-1:1000
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-
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1:200
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1:200
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1:200
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-
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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HER2/ErbB2
Rabbit Polyclonal Antibody
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Category
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Polyclonal
antibody(pAb); Primary antibody
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Isotype
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IgG
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Purification
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Peptide XYfinity
purified
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About the
Immunogen
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Immunogen
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This antibody
is produced by immunizing rabbits with a synthetic peptide (KLH-coupled)
corresponding to human ErbB2.
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Gene ID
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2064
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SwissProt
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P04626
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Synonyms
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CerbB2
antibody; CerbB2/neu protein antibody; ErbB2 antibody; HER2 antibody
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Category
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RTK
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Background
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HER2 is a
member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family.
Amplification or overexpression of this oncogene has been shown to play an
important role in the development and progression of certain aggressive types
of breast cancer. In recent years the protein has become an important
biomarker and target of therapy for approx. 30% of breast cancer patients.
Over-expression is also known to occur in ovarian, stomach, and aggressive
forms of uterine cancer, such as uterine serous endometrial carcinoma. The
expression of HER2 is regulated by signaling through estrogen receptors.
Normally, estradiol and tamoxifen acting through the estrogen receptor
down-regulate the expression of HER2. However, when the ratio of the
coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of
HER2 is upregulated in the presence of tamoxifen, leading to
tamoxifen-resistant breast cancer.
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包装清单：
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产品编号
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产品名称
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包装
|
|
XY0177
|
HER2/ErbB2
Rabbit Polyclonal Antibody
|
50μl
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AZ050
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Western一抗稀释液
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50ml
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—
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说明书
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1份
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保存条件：
HER2 / ErbB2
Rabbit Polyclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项：
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10