Recombinant Human p16-INK4a
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产品名称: Recombinant Human p16-INK4a
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Human p16-INK4a由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Human p16-INK4a所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Human p16-INK4a
的详细介绍
Recombinant Human p16-INK4a
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产品编号
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产品名称
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产品包装
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产品价格
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XY7181-1mg
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Recombinant
Human p16-INK4a
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1mg
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12354.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Human
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1029
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P42771
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E. coli
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156aa
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16.5kDa
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－
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About this
Antibody
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Name
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Recombinant
Human p16-INK4a (Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A,
Isoform 1; rHup16-INK4a)；重组人细胞周期蛋白依赖激酶抑制剂2A，同工酶1
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Synonyms
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ARF; CDK4I;
CDKN2A; INK4a; MLM; p14ARF; p16; p19ARF; ARF; CDK4 inhibitor p16-INK4;
CDK4IP14ARF; CDKN2; cell cycle negative regulator beta; CMM2P16-INK4A;
Cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A;
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); INK4;
INK4A; INK4a; MLMP16INK4; MTS-1; MTS1P14; Multiple tumor suppressor 1; p14;
p14ARF; P16; p16; p16-INK4; p16INK4a; p16INK4A; P16INK4A; p16-INK4a; p19;
P19; p19ARF; p19Arf; P19ARF; TP16
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Purity
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>96% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Data Not
Available.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in PBS, pH7.4.
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Endotoxin
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Less than 1EU/μg of rHuP16-INK4a as determined by LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions
should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Others
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Background
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Cyclin-dependent
kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity
of CDKs. Two major classes of CDK inhibitors have been identified. The p16
family (p15, p16, p18 and p19) binds to and inhibits the activities of CDK4
and CDK6. The p21 family (p21, p27, p28 and p57) can bind to broad range of
CDK-cyclin complexes and inhibit their activities. CDKIs are capable of
suppressing growth, and several lines of evidence strongly suggest that at
least some CDKIs may be tumor suppressor proteins. p16-INK4A is the member of
p16 family and is encoded by CDKN2A gene in humans. It has three isoforms,
which are wildly expressed but not detected in brain or skeletal muscle,
except that isoform 3 is pancreas-specific. Defects in p16INK4A are a cause
of Li-Fraumeni syndrome (LFS) and melanoma-astrocytoma syndrome (MASTS).
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Amino Acid
Sequence
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MEPAAGSSME PSADWLATAA ARGRVEEVRA
LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA
GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD
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包装清单:
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产品编号
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产品名称
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包装
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XY7181-10μg
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Recombinant
Human p16-INK4a
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10μg
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XY7181-50μg
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Recombinant
Human p16-INK4a
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50μg
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XY7181-100μg
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Recombinant
Human p16-INK4a
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100μg
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XY7181-1mg
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Recombinant
Human p16-INK4a
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。