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产品名称: Recombinant Human MIC-A
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Human MIC-A由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Human MIC-A所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Human MIC-A
的详细介绍
Recombinant Human MIC-A
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产品编号
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产品名称
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产品包装
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产品价格
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XY7140-1mg
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Recombinant
Human MIC-A
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1mg
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12354.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Human
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100507436
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Q29983
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E. coli
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284aa
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32.8kDa
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－
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About this
Antibody
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Name
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Recombinant
Human MIC-A (Recombinant Human MHC Class I PolypeptideRelated Sequence A;
rHuMIC-A)；重组人MIC类多肽相关序列A
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Synonyms
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FLJ60820;
MGC111087; PERB11.1
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Purity
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>95% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Fully
biologically active when compared to standard. The specific activity is
determined by binding MICA antibody in ELISA.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in 30% Acetonitrile,
0.1% TFA.
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Endotoxin
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Less than 1EU/μg of rHuMIC-A as determined by LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration less than 0.2mg/ml. Stock solutions
should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Others
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Background
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MIC-A (MHC
class I chain-related gene A) is a single-pass type I member protein. It is
expressed on the cell surface in gastric epithelium, endothelial cells and
fibroblasts and in the cytoplasm in keratinocytes and monocytes.
Additionally, MIC-A can be induced by bacterial and viral infections. It
shares 85% amino acid identity with MIC-B and they are distantly related to
the MHC class I proteins. Because they possess three extracellular Ig-like
domains, but unlike classical MHC class I molecules. They do not form a
heterodimer with beta2 microglobulin, but bind as a monomer to a KLRK1/NKG2D
that is an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ αβ T cells. Recognition of MICA by NKG2D results in the activation
of cytolytic activity and/or cytokine production by these effector cells.
MIC-A recognition plays an important role in tumor surveillance, viral
infections, and autoimmune diseases.
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Amino Acid
Sequence
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EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG
QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE
DNSTRSSQHF YYDGELFLSQ NLETEEWTVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR
YLESGVVLRR TVPPMVNVTR SEASEGNITV TCRASSFYPR NIILTWRQDG VSLSHDTQQW GDVLPDGNGT
YQTWVATRIC RGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHW
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包装清单:
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产品编号
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产品名称
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包装
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XY7140-10μg
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Recombinant
Human MIC-A
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10μg
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XY7140-50μg
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Recombinant
Human MIC-A
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50μg
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XY7140-100μg
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Recombinant
Human MIC-A
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100μg
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XY7140-1mg
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Recombinant
Human MIC-A
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。