Recombinant Human IL-36β, 157a.a.
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产品名称: Recombinant Human IL-36β, 157a.a.
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Human IL-36β, 157a.a.由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Human IL-36β, 157a.a.所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Human IL-36β, 157a.a.
的详细介绍
Recombinant Human IL-36β, 157a.a.
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产品编号
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产品名称
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产品包装
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产品价格
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XY255-1mg
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Recombinant
Human IL-36β, 157a.a.
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1mg
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26773.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Human
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27177
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Q9NZH7
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E. coli
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157aa
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17.7kDa
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－
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About this
protein
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Name
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Recombinant
Human IL-36β, 157a.a. (Recombinant Human Interleukin-36β, 157a.a.; rHuIL-36β, 157a.a.)；重组人白细胞介素36β，157a.a.
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Synonyms
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IL36B; IL1F8;
IL1H2
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Purity
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>97% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Fully
biologically active when compared to standard. The specific activity is
determined by its binding ability in a functional ELISA. Immobilized rHuIL-36β at 1μg/ml can bind recombinant human IL-1
Rrp2 Fc Chimera with a range of 0.15-5μg/ml.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in PBS, pH7.4.
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Endotoxin
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Less than 1EU/μg of rHuIL-36β, 157a.a. as determined by
LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should
be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Cytokine
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Background
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Interleukin-36
(IL-36) is a pro-inflammatory cytokine which plays an important role in the
pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and
IL-1F9) are IL-1 family members that signal through the IL-1 receptor family
members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be
expressed at higher levels in psoriatic plaques than in symptomless psoriatic
skin or healthy control skin. Furthermore, it can stimulate production of
interleukin-6 and interleukin-8 in synovial fibroblasts, articular
chondrocytes and mature adipocytes. Two alternatively spliced transcript
variants encode distinct (164 or 157 residues) protein isoforms that differ
in their C-terminal 70 amino acid residues have been reported and IL-36β isoform 2 is synthesized as a 157a.a. protein. Specifically,
human IL-36β shares low sequence identity with IL-1β, IL-36RA, IL-36α and IL-36γ.
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Amino Acid
Sequence
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MNPQREAAPK SYAIRDSRQM VWVLSGNSLI
AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA
QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE
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包装清单:
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产品编号
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产品名称
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包装
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XY255-2μg
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Recombinant
Human IL-36β, 157a.a.
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2μg
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XY255-10μg
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Recombinant
Human IL-36β, 157a.a.
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10μg
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XY255-100μg
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Recombinant
Human IL-36β, 157a.a.
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100μg
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XY255-1mg
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Recombinant
Human IL-36β, 157a.a.
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。