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产品名称: Recombinant Human IL-17
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Human IL-17由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Human IL-17所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Human IL-17
的详细介绍
Recombinant Human IL-17
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产品编号
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产品名称
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产品包装
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产品价格
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XY201-1mg
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Recombinant
Human IL-17
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1mg
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15444.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Human
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3605
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Q16552
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E. coli
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132aa
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31kDa
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－
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About this
protein
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Name
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Recombinant
Human IL-17 (Recombinant Human Interleukin-17; rHuIL-17)；重组人白细胞介素17
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Synonyms
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CTLA8; IL-17;
IL-17A; IL17
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Purity
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>95% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Fully
biologically active when compared to standard. The ED50 as determined by
inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5ng/ml,
corresponding to a specific activity of >1.3×105IU/mg.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in PBS, pH7.4.
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Endotoxin
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Less than 1EU/μg of rHuIL-17 as determined by LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in 4mM HCl to a concentration of 0.1-1.0mg/ml.
Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Cytokine
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Background
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Human
Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the
chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B,
IL-17C, IL-17D, IL-17E and IL-17F. They have a similar protein structure,
with four highly conserved cysteine residues critical to their 3-dimensional
shape, but no sequence similarity to any other known cytokines. Interleukin
17 is a T cell-expressed pleiotropic cytokine that exhibits a high degree of
homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri.
Mature IL-17 containing one potential N-linked glycosylation site. Both
recombinant and natural IL-17 have been shown to exist as disulfide linked
homodimers. At the amino acid level, IL-17 exhibits 63% amino acid identity
with mouse IL-17. High levels of human IL-17 were induced from primary
peripheral blood CD4+ T cells upon
stimulation and they can induce stromal cells to produce proinflammatory and
hematopoietic cytokines.
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Amino Acid
Sequence
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GITIPRNPGC PNSEDKNFPR TVMVNLNIHN
RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR
REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA
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包装清单:
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产品编号
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产品名称
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包装
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XY201-5μg
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Recombinant
Human IL-17
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5μg
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XY201-25μg
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Recombinant
Human IL-17
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25μg
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XY201-100μg
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Recombinant
Human IL-17
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100μg
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XY201-1mg
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Recombinant
Human IL-17
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。