G蛋白偶联受体120抗体
规格：1mg/1ml
英文名： GPR120
别名： G protein coupled receptor 120; GPCR GPR120; G protein coupled receptor 129; G protein coupled receptor GT01; G protein coupled receptor PGR 4; G protein coupled receptor PGR4; G-protein coupled recep
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human G protei
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞膜
G蛋白偶联受体120抗体产品介绍：background: GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion G蛋白偶联受体120抗体of GLP-1 is critical in the treatment of diabetes. Function: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids. Subunit: Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation. Subcellular Location: Cell membraneG蛋白偶联受体120抗体. Colocalized with ARRB2 following DHA treatment. Tissue Specificity: Abundant expression in the intestinal tract. Post-translational modifications: Phosphorylated. FFA stimulation facilitates phosphorylation. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 338557 Database links: Entrez Gene: 338557 Human Omim: 609044 Human SwissProt: Q5NUL3 Human Unigene: 661022 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体120抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid