磷酸化死亡相关蛋白激酶3抗体
规格：1mg/1ml
英文名： phospho-ZIP Kinase (Thr265)
别名： ZIP Kinase (phospho T265); p-ZIP Kinase (phospho T265) DAP kinase 3; DAP like kinase; DAP-like kinase; Dapk 3; DAPK3; DAPK3_HUMAN; Death associated kinase 3; Death associated protein kinase 3; Death-a
分子量： 53kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KKLH conjugated synthesised phosphopeptide derived from huma
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆
磷酸化死亡相关蛋白激酶3抗体产品介绍：background: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008] Function: Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Subcellular Location: Nucleus. Cytoplasm. Nucleus > PML body. Relocates to the cytoplasm on binding PAWR where the 磷酸化死亡相关蛋白激酶3抗体complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase. Post-translational modifications: Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) 磷酸化死亡相关蛋白激酶3抗体formation in the nucleus. Autophosphorylated. Phosphorylated by ROCK1. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. Contains 1 protein kinase domain. Gene ID: 1613 Database links: Entrez Gene: 1613 Human Entrez Gene: 13144 Mouse Omim: 603289 Human SwissProt: O43293 Human SwissProt: O54784 Mouse Unigene: 631844 Human Unigene: 10294 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化死亡相关蛋白激酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid