环指蛋白61抗体
规格：1mg/1ml
英文名： RNF61/MKRN1
别名： RING finger protein 61; E3 ubiquitin-protein ligase makorin-1; Makorin; Makorin ring finger protein 1; MKRN 1; MKRN-1; mkrn1; MKRN1_HUMAN; Ring finger protein 1; RNF61.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MKRN1/RN
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
环指蛋白61抗体产品介绍：background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has 环指蛋白61抗体negative and positive effects on RNA polymerase II-dependent transcription. Subunit: Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis. Tissue Specificity: Ubiquitous. Post-translational modifications: Auto-ubiquitinated; which leads to proteasomal degradation. Similarity: Contains 4 C3H1-type zinc fingers. Contains 1 RING-type zinc finger. Gene ID: 23608 Database links: Entrez Gene: 23608 Human Entrez Gene: 54484 Mouse Entrez Gene: 296988 Rat Omim: 607754 Human SwissProt: Q9UHC7 Human SwissProt: 环指蛋白61抗体Q9QXP6 Mouse Unigene: 728819 Human Unigene: 270484 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白61抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid