沉默调节蛋白5抗体
规格：1mg/1ml
英文名： SIRT5
别名： NAD dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin-5; Silent mating type information regulation 2 S.cerevisiae homolog 5; Sir2 like 5; Sir2-lik
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from hu SIRT5
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
沉默调节蛋白5抗体产品介绍：background: Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA (ribosomal RNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT5 (NAD-dependent deacetylase sirtuin-5), also known as SIR2L5, is a 310 amino acid member of the class III sirtuins. Localized to mitochrondria and expressed throughout the body, SIRT5 is an NAD-dependent deacetylase that may link metabolic aging processes 沉默调节蛋白5抗体in humans. SIRT5 contains one deacetylase-sirtuin-type domain and can be deactivated by suramin, a drug that blocks the binding of various growth factors. Two isoforms of SIRT5 exist due to alternative splicing events. Subcellular Location: Mitochondrion matrix. Mitochondrion intermembrane space. Tissue Specificity: Widely expressed. Database links: Entrez Gene: 23408 Human Entrez Gene: 68346 Mouse Omim:沉默调节蛋白5抗体 604483 Human SwissProt: Q3ZBQ0 Cow SwissProt: E2RDZ6 Dog SwissProt: Q9NXA8 Human SwissProt: Q8K2C6 Mouse SwissProt: Q5R6G3 Orangutan Unigene: 567431 Human Unigene: 594133 Human Unigene: 35325 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产沉默调节蛋白5抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid