1号染色体开放阅读框80抗体
规格：1mg/1ml
英文名： C1orf80
别名： dorsalization-associated protein; AIDA; AIDA_HUMAN; Axin interaction partner and dorsalization antagonist; Axin interactor; Axin interactor, dorsalization associated; Chromosome 1 open reading frame 8
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C1orf180
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：
1号染色体开放阅读框80抗体产品介绍：background: AIDA, also known as C1orf80, is a 306 amino acid protein that belongs to the axin interactor family. Expressed in a variety of tissues, including skeletal muscle and heart, AIDA functions as a ventralizing factor during embryogenesis, disrupting Axin homodimerization and inhibiting Axin-mediated JNK activation. Axin, a scaffold protein, is important for both JNK signaling and the canonical Wnt pathway, two processes that play an essential role in embryonic dorsoventral patterning. Disruption of Axin by AIDA results in the negative regulation of JNK and Wnt signaling, thereby affecting embryonic developmental events. Three isoforms of AIDA1号染色体开放阅读框80抗体 exist due to alternative splicing events. Function: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Subunit: Interacts with AXIN1 (By similarity). Tissue Specificity: Widely expressed in ***** tissues, with highest expression in the heart and skeletal muscle. Similarity: Belongs to the AIDA family. Database links: Entrez Gene: 64853 1号染色体开放阅读框80抗体Human Omim: 612375 Human SwissProt: Q96BJ3 Human Unigene: 156625 Human Unigene: 534965 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
1号染色体开放阅读框80抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid