钾/钠超极化激活环核苷酸门控通道蛋白3抗体
规格：1mg/1ml
英文名： HCN3
别名： Hcn3; HCN3_HUMAN; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; KIAA1535; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCN3
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞膜
钾/钠超极化激活环核苷酸门控通道蛋白3抗体产品介绍：background: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a C-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly 钾/钠超极化激活环核苷酸门控通道蛋白3抗体concentrated in the hypothalamus and thalamus, respectively. Function: Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity). Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. Database links: Entrez Gene: 57657 Human Entrez Gene:钾/钠超极化激活环核苷酸门控通道蛋白3抗体 15168 Mouse Entrez Gene: 114245 Rat Omim: 609973 Human SwissProt: Q9P1Z3 Human SwissProt: O88705 Mouse SwissProt: Q9JKA8 Rat Unigene: 706960 Human Unigene: 389461 Mouse Unigene: 48801 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产钾/钠超极化激活环核苷酸门控通道蛋白3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid