热休克蛋白β7抗体
规格：1mg/1ml
英文名： HSPβ7
别名： Cardiovascular heat shock protein; cvHsp; Heat shock 27kda protein family member 7; Heat shock protein beta 7; Heat shock protein beta-7; Hsp25 2; HspB7; HSPB7_HUMAN; Hypothetical protein flj34956; RP
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSPβ7/cv
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
热休克蛋白β7抗体产品介绍：background: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. 热休克蛋白β7抗体In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting. Subunit: Interacts with C-terminal domain of actin-binding protein 280. Subcellular Location: Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Tissue Specificity: Isoform 1 is highly expressed in ***** and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart. Similarity: Belongs to the small heat shock protein (HSP20) family. Database links: Entrez Gene: 27129 Human Omim: 610692 Human SwissProt: Q9UBY9 Human热休克蛋白β7抗体 Unigene: 502612 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
热休克蛋白β7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 信号转导 细胞骨架
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid