红细胞膜蛋白4.2抗体
规格：1mg/1ml
英文名： protein 4.2
别名： protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EPB42/pr
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
红细胞膜蛋白4.2抗体产品介绍：background: protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5. Function: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Subunit: Oligomer. Interacts with the cytoplasmic domain of SLC4A1/band 3 anion transport protein. Subcellular Location: Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes. Post-translational modifications: Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42. DISEASE: Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally红细胞膜蛋白4.2抗体 shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Database links: Entrez Gene: 2038 Human Omim: 177070 Human SwissProt: P16452 Human Unigene: 368642 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Involvement in disease:Defects in EPB42 are the cause of spherocytosis 红细胞膜蛋白4.2抗体type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
红细胞膜蛋白4.2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid