抗药蛋白抗体
规格：1mg/1ml
英文名： Sorcin
别名： 22 kDa protein; Calcium binding protein amplified in mutlidrug resistant cells; CP 22; CP-22; CP22; SCN; Sorcin (class 4 gene); Sorcin; SORCN_HUMAN; SRI; V19.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SR1/Sorc
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
抗药蛋白抗体产品介绍：background: Sorcin is a highly conserved protein, with 95% homology between hamster and human sorcin sequences. Sorcin has four putative Ca-binding domains, two of which exhibit strong homology to calmodulin “EF hand” motifs. Calcium binding directly to sorcin has been demonstrated by in vitro assays. Sorcin is closely related to members of calpain and sarcoplasmic Ca2+-binding protein subfamilies. Sorcin undergoes calcium-dependent translocation from the cytosol to cellular membranes. Sorcin binds to and modulates ryanodine receptors and is widely distributed including heart and brain tissues. At the subcellular level, sorcin localizes to T-tubule junctions of cardiac sarcoplasmic reticulum. Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium 抗药蛋白抗体homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. Subunit: Homodimer. Interacts with GCA, RYR2 and ANXA7. Subcellular Location: Cytoplasm. Sarcoplasmic reticulum membrane. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. Tissue Specificity: Detected in cardiac myocytes. Similarity: Contains 4 EF-hand domains. 抗药蛋白抗体Database links: Entrez Gene: 420538 Chicken Entrez Gene: 6717 Human Entrez Gene: 109552 Mouse Entrez Gene: 683667 Rat Omim: 182520 Human SwissProt: P30626 Human SwissProt: Q6P069 Mouse Unigene: 489040 Human Unigene: 96211 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抗药蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 结合蛋白 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid