WASP结合蛋白抗体
规格：1mg/1ml
英文名： WIPF2
别名： WAS/WASL interacting protein family member 2; WASP binding protein; WASP interacting protein related protein; WICH; WIP and CR16 homologous protein; WIP related protein; WIPF 2; WIR; WIPF2_HUMAN.
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WIPF2
交叉反应：Human, Mouse, Rat, Dog, Pig,
细胞定位：细胞浆
WASP结合蛋白抗体产品介绍：background: WIRE, also known as WIPF2 (WAS/WASL interacting protein family, member 2) or WICH, is a 440 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one WH2 domain. Expressed ubiquitously with highest expression in colon, brain, lung and stomach, WIRE functions as an N-WASP-interacting protein that plays an important role in the organization and mobilization of the Actin cytoskeleton. Additionally, WIRE is involved in the formation of cell surface protrusions and may also provide a link between the cytoskeletal machinery and PDGF-B receptors. Multiple alternatively spliced isoforms of WIRE exist andWASP结合蛋白抗体 are encoded by a gene that maps to human chromosome 17. Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Subunit: Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of WASP结合蛋白抗体focal adhesions. No interaction was seen with WASF2 and WASF3. Subcellular Location: Cytoplasm; cytoskeleton. Similarity: Belongs to the verprolin family. Contains 1 WH2 domain. Database links: Entrez Gene: 147179 Human Omim: 609692 Human SwissProt: Q8TF74 Human Unigene: 421622 Human Unigene: 731598 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
WASP结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid