原癌基因wnt7a蛋白抗体
规格：1mg/1ml
英文名： WNT7A
别名： Protein Wnt-7a; wnt 7a;Protein Wnt-7a precursor; proto-oncogene wnt7a protein; wingless-type MMTV integration site family, member 7A; WNT7A; WNT7A_HUMAN.
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WNT7A
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
细胞定位：细胞外基质 分泌型蛋白
原癌基因wnt7a蛋白抗体产品介绍：background: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity). Subunit: Interacts with PORCN. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and ***** brain. DISEASE: Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]. A syndrome of severe deficiency of the extremities due to 原癌基因wnt7a蛋白抗体hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Similarity: Belongs原癌基因wnt7a蛋白抗体 to the Wnt family. Gene ID: 7476 Database links: Entrez Gene: 7476 Human Entrez Gene: 533782 Cow Entrez Gene: 607180 Dog Entrez Gene: 100055450 Horse Entrez Gene: 22421 Mouse Entrez Gene: 100355697 Rabbit Entrez Gene: 114850 Rat Omim: 601570 Human SwissProt: O00755 Human SwissProt: P24383 Mouse Unigene: 72290 Human Unigene: 56964 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
原癌基因wnt7a蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid