烟碱型乙酰胆碱受体α3抗体
规格：1mg/1ml
英文名： CHRNA3
别名： Nicotinic Acetylcholine Receptor alpha 3; ACHA3_HUMAN; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypep
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHRNA3/A
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
烟碱型乙酰胆碱受体α3抗体细胞定位：细胞膜
产品介绍：background: Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR?, also known as LNCR2, PAOD2, NACHRA3 or CHRNA3, is a 505 amino acid multi-pass membrane protein that belongs to the ligand-gated ion channel receptor family and may play a role in neurotransmission. Function: After烟碱型乙酰胆碱受体α3抗体 binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. Subunit: Neuronal AChR is composed of two different types ofsubunits: alpha and beta. Alpha-3 subunit can be combined to beta-2or beta-4 to give rise to functional receptors. Interacts withRIC3; which is required for proper folding and assembly. Subcellular Location: Cell junction, synapse, postsynaptic cellmembrane; Multi-pass membrane protein. Cell membrane; Multi-passmembrane protein. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9)family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Alpha-3/CHRNA3 烟碱型乙酰胆碱受体α3抗体sub-subfamily. Database links: Entrez Gene: 386578 Chicken Entrez Gene: 282702 Cow Entrez Gene: 1136 Human Entrez Gene: 110834 Mouse Entrez Gene: 25101 Rat Omim: 118503 Human SwissProt: P09481 Chicken SwissProt: Q07263 Cow SwissProt: P32297 Human SwissProt: Q8R4G9 Mouse SwissProt: P04757 Rat Unigene: 89605 Human Unigene: 63569 Mouse Unigene: 10996 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
烟碱型乙酰胆碱受体α3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid