双特异性酪氨酸磷酸化调节激酶1B抗体
规格：1mg/1ml
英文名： Dyrk1B
别名： Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B; Dual specificity tyrosine phosphorylation regulated kinase 1B; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; DYR 1B;
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIRK/Dyr
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
双特异性酪氨酸磷酸化调节激酶1B抗体产品介绍：background: Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is self regulated by tyrosine phosphorylation. Several related mammalian proteins compose the Dyrk family of dual specificity protein kinases, including Dyrk1A, Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B. The Dyrk family members are thought to be involved in the regulation of cellular growth and/or development. Dyrk1B localizes to the nucleus in muscle and testis. Specifically, Dyrk1B plays a critical role in muscle differentiation by regulating motility, transcription, cell cycle progression and cell survival. Dyrk1B is also found is several solid tumors, where it acts as a downstream effector of Rac1 or K-ras to mediate cell survival. Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma 双特异性酪氨酸磷酸化调节激酶1B抗体cell survival in mitogen-poor environments. Subunit: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7. Subcellular Location: Nucleus. Tissue Specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Post-translational modifications: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required 双特异性酪氨酸磷酸化调节激酶1B抗体for dimerization. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: Q9Y463.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双特异性酪氨酸磷酸化调节激酶1B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid