磷脂酸磷酸酶HTPAP抗体
规格：1mg/1ml
英文名： DPPL1
别名： diacylglycerol pyrophosphate like 1; DPPL1; EC=3.1.3.4; HTPAP; Phosphatidate phosphatase PPAPDC1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; PPAPDC1B; PPC1B_HUMAN.
分子量： 29kD
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DPPL1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
磷脂酸磷酸酶HTPAP抗体产品介绍：background: DPPL1 and is a 223 amino acid protein that is localized to the cellular membrane. HTPAP is a multi-pass membrane protein which is thought to possess six transmembrane spanning domains and is expressed as two isoforms. HTPAP is a member of the PAP related phosphoesterase family and the gene encoding HTPAP is highly conserved among many species. HTPAP functions as a PAP for lipid phosphate substrates, including PA (phosphatidate), LPA (lysophatidate) and DGPP (diacylglycerol pyrophosphate), but preferentially targets DGPP. Breast cancer tumors, specifically those in which ER (estrogen receptor) is present in high amounts, exhibit upregulation of the gene which encodes HTPAP and HTPAP is thought to increase ER activity. Due to the overexpression of HTPAP in ductal breast carcinomas and the observation that, in cases of lower HTPAP expression, tumors grew slower, HTPAP is thought to be an oncogene. In contrast,磷脂酸磷酸酶HTPAP抗体 the gene encoding HTPAP is downregulated in HCC (hepatocellular carcinoma) and is thought to inhibit lung metastasis. Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Ubiquitous. Similarity: Belongs to the PA-phosphatase related phosphoesterase family. Database links: Entrez Gene: 84513 Human Entrez Gene磷脂酸磷酸酶HTPAP抗体: 71910 Mouse Entrez Gene: 680466 Rat Omim: 610626 Human SwissProt: Q8NEB5 Human SwissProt: Q3UMZ3 Mouse Unigene: 567619 Human Unigene: 385055 Mouse Unigene: 199008 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产磷脂酸磷酸酶HTPAP抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid