ras癌基因家族RAB20抗体
规格：1mg/1ml
英文名： RAB20
别名： FLJ20429; RAB20; RAB20 member RAS oncogene family; RAB20_HUMAN; Ras related protein Rab20; Ras-related protein Rab-20.
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Rab20
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
ras癌基因家族RAB20抗体产品介绍：background: The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 20 (Ras-related protein Rab-20) is a 234 amino acid protein that localizes to the golgi apparatus and belongs to the Rab subfamily of small GTPases. Expressed in normal and cancerous pancreatic tissue, Rab 20 plays an important role in apical endocytosis and recycling and may be involved in the development of exocrine pancreatic adenocarcinomas Function: Plays a role in apical endocytosis/recycling. Plays a role inras癌基因家族RAB20抗体 the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Subcellular Location: Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. Tissue Specificity:ras癌基因家族RAB20抗体 Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). Similarity: Belongs to the small GTPase superfamily. Rab family. Gene ID: 55647 Database links: Entrez Gene: 55647 Human SwissProt: Q9NX57 Human Unigene: 729392 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ras癌基因家族RAB20抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞类型标志物 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid