酪氨酸蛋白激酶受体B4抗体
规格：1mg/1ml
英文名： EPHB4
别名： Eph receptor B4; EPHB4; EPHB4_HUMAN; Ephrin type-B receptor 4; Hepatoma Transmembrane Kinase; HTK; MYK1; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11.
分子量： 107kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Eph rece
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞膜
酪氨酸蛋白激酶受体B4抗体产品介绍：background: Receptor for members of the ephrin-B family. Binds to ephrin-B2. May have a role in events mediating differentiation and development. Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Abundantly 酪氨酸蛋白激酶受体B4抗体expressed in placenta and in a range of primary tissues and malignant cell lines. Expressed in fetal, but not *****, brain, and in primitive and myeloid, but not lymphoid, hematopoietic cells. Post-translational modifications: Phosphorylated; autophosphorylation is stimulated by EFNB2. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin 酪氨酸蛋白激酶受体B4抗体type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. Gene ID: 2050 Database links: Entrez Gene: 2050 Human Entrez Gene: 13846 Mouse Omim: 600011 Human SwissProt: P54760 Human SwissProt: P54761 Mouse Unigene: 437008 Human Unigene: 34533 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酪氨酸蛋白激酶受体B4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 神经生物学 信号转导 干细胞 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid