E3泛素蛋白连接酶HACE1抗体
规格：1mg/1ml
英文名： HACE1
别名： E3 ubiquitin-protein ligase HACE1; HACE 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; KIAA1320.
分子量： 90-102kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HACE1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
E3泛素蛋白连接酶HACE1抗体产品介绍：background: E3 ubiquitin-protein ligase that may function in cellular proteins degradation. HACE1 has also been shown to be down-regulated in many human tumours and is a putative candidate tumor suppressor. Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. Subunit: Interacts with RARB (By similarity). Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit. Subcellular Location: Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Tissue Specificity: Expressed in multiple tissues including heart, brain and kidney. DISEASE: Note=Defects in E3泛素蛋白连接酶HACE1抗体HACE1 are a cause of Wilms tumor (WT). WT is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. HACE1 is epigenetically down-regulated in sporadic Wilms tumor. Moreover, a t(5;6)(q21;q21) translocation that truncates HACE1 has been found in a child with bilateral, young-onset Wilms tumor. Similarity: Contains 6 ANK repeats. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Gene ID: 57531 Database links: Entrez Gene: 527565 Cow Entrez Gene: 100733867 Guinea pig Entrez Gene: 100071887 Horse E3泛素蛋白连接酶HACE1抗体Entrez Gene: 57531 Human Entrez Gene: 209462 Mouse Entrez Gene: 100156102 Pig Entrez Gene: 361866 Rat Omim: 610876 Human SwissProt: F1N6G5 Cow SwissProt: Q8IYU2 Human SwissProt: Q3U0D9 Mouse SwissProt: D3ZBM7 Rat Unigene: 434340 Human Unigene: 458633 Mouse Unigene: 28116 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
E3泛素蛋白连接酶HACE1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 信号转导 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid