F-box蛋白家族FBXO31抗体
规格：1mg/1ml
英文名： FBXO31
别名： F box only protein 31; FBX14; FBX31; FBXO14; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor; FBX31_HUMAN.
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FBXO31 (
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
F-box蛋白家族FBXO31抗体产品介绍：background: FBXO31 belongs to the F-box protein family. Such proteins are characterized by an F-box motif of approximately 40 residues. F-box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains. There are two different isoforms. Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Subunit: F-box蛋白家族FBXO31抗体Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Tissue Specificity: Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Post-translational modifications: Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. Similarity: Belongs to the FBXO31 family. Contains 1 F-box domain. Gene ID: 79791 Database links: Entrez Gene: 79791 HumanF-box蛋白家族FBXO31抗体 Entrez Gene: 76454 Mouse Omim: 609102 Human SwissProt: Q5XUX0 Human SwissProt: Q3TQF0 Mouse Unigene: 567582 Human Unigene: 467749 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
F-box蛋白家族FBXO31抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid