Dab2相互作用蛋白抗体
规格：1mg/1ml
英文名： DAB2IP
别名： AF9Q34; AIP1; ASK interacting protein; DAB2P_HUMAN; ASK interacting protein 1; ASK1 interacting protein 1; DAB2 interacting protein; DAB2 interaction protein; DAB2P; DIP1/2; Disabled homolog 2 interac
分子量： 132kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DAB2IP
Dab2相互作用蛋白抗体交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞浆 细胞膜
产品介绍：background: DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. It also interacts with MAP3K5 to disrupt the association of MAP3K5 with the inhibitory 14-3-3 complex. Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene. Subunit: Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma membrane, exists in an inactive form complexed with TNFR1. In response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm and forms part of an intracellular signaling complex comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is induced by TNF. Interacts with DAB1 and DAB2 (By similarity). Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Subcellular Location: Membrane. Cytoplasm. Note=Translocates to the cytoplasm in response toDab2相互作用蛋白抗体 TNF. Tissue Specificity: Low expression in prostate. Down-regulated in prostate cancer. DISEASE: Note=A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. Similarity: Contains 1 C2 domain. Contains 1 PH domain. Contains 1 Ras-GAP domain. Gene ID: Dab2相互作用蛋白抗体153090 Database links: Entrez Gene: 153090 Human Entrez Gene: 69601 Mouse Entrez Gene: 192126 Rat Omim: 609205 Human SwissProt: Q5VWQ8 Human SwissProt: Q3UHC7 Mouse SwissProt: Q6P730 Rat Unigene: 522378 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Dab2相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid