乳腺癌相关抗原BRCAA1抗体
规格：1mg/1ml
英文名： BRCAA1
别名： ARID 4B; ARID domain-containing protein 4B; ARID4B; AT rich interactive domain 4B (Rbp1 like); AT rich interactive domain 4B; BCAA; BRCAA 1; BRCAA1; Breast cancer associated antigen 1; Breast cancer a
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BRCAA1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞核 细胞浆
乳腺癌相关抗原BRCAA1抗体产品介绍：background: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]乳腺癌相关抗原BRCAA1抗体. Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Subunit: Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2. Subcellular Location: Nucleus (By similarity). Cytoplasm. 乳腺癌相关抗原BRCAA1抗体Note=Cytoplasmic in breast cancer cells. Tissue Specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. Similarity: Contains 1 ARID domain. Database links: UniProtKB/Swiss-Prot: Q4LE39.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乳腺癌相关抗原BRCAA1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid