致癌基因n-Myc抗体
规格：1mg/1ml
英文名： n-Myc
别名： bHLHe37; Class E basic helix-loop-helix protein 37; MODED; MYCN; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human n-Myc
交叉反应：Human, Mouse, Rat, Pig, Cow,
致癌基因n-Myc抗体细胞定位：细胞核
产品介绍：background: This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]. Function: May function as a transcription factor. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Subcellular Location: Nucleus. DISEASE: Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses. Defects in MYCN are the致癌基因n-Myc抗体 cause of Feingold syndrome type 1 (FGLDS1) [MIM:164280]. A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene:致癌基因n-Myc抗体 4613 Human Entrez Gene: 18109 Mouse Entrez Gene: 298894 Rat Omim: 164840 Human SwissProt: P04198 Human SwissProt: P03966 Mouse SwissProt: Q63379 Rat Unigene: 25960 Human Unigene: 16469 Mouse Unigene: 81116 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
致癌基因n-Myc抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid