RAS家族关联结构域蛋白6抗体
规格：1mg/1ml
英文名： RASSF6
别名： Putative RAS binding protein; Ras association domain containing protein 6.RASF6_HUMAN
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RASSF6
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：
RAS家族关联结构域蛋白6抗体产品介绍：background: This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]. Function: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effectorRAS家族关联结构域蛋白6抗体 protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). Subunit: Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779). Tissue Specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived fromRAS家族关联结构域蛋白6抗体 breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. Similarity: Contains 1 Ras-associating domain. Contains 1 SARAH domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RAS家族关联结构域蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid