整合素和生长因子样蛋白1抗体
规格：1mg/1ml
英文名： LIMS1
别名： Lims1l; LIM and senescent cell antigen like domains 1; Particularly interesting new Cys His protein 1; PINCH; PINCH1; Renal carcinoma antigen NY REN 48; LIMS1_HUMAN.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LIMS1
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow,
细胞定位：
整合素和生长因子样蛋白1抗体产品介绍：background: Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. Subunit: Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain,整合素和生长因子样蛋白1抗体 and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors. Subcellular Location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in most tissues except in the brain. Similarity: Contains 5 LIM zinc-binding domains. Gene ID: 3987 Database links: Entrez Gene: 3987 Human Entrez Gene: 110829 Mouse整合素和生长因子样蛋白1抗体 Entrez Gene: 499443 Rat Omim: 602567 Human SwissProt: P48059 Human SwissProt: Q99JW4 Mouse Unigene: 597715 Human Unigene: 613268 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素和生长因子样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid