蛋白磷酸酶PP2A癌抑制蛋白抗体
规格：1mg/1ml
英文名： CIP2A/p90 Autoantigen
别名： p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen.
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human p90 Auto
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：细胞浆 细胞膜
蛋白磷酸酶PP2A癌抑制蛋白抗体产品介绍：background: Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) 蛋白磷酸酶PP2A癌抑制蛋白抗体and colon cancer. Subunit: Interacts with MYC. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. Tissue Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). Database links: Clone ID: 57650 Human 蛋白磷酸酶PP2A癌抑制蛋白抗体Entrez Gene: 57650 Human Entrez Gene: 224171 Mouse Entrez Gene: 360711 Rat Omim: 610643 Human SwissProt: Q8TCG1 Human SwissProt: Q8BWY9 Mouse SwissProt: D3ZF50 Rat Unigene: 591308 Human Unigene: 24491 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白磷酸酶PP2A癌抑制蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid