畸胎瘤癌基因RAS相关病毒抗体
规格：1mg/1ml
英文名： RRAS2
别名： Oncogene RRAS2; Oncogene TC21; Ras like protein TC21; Ras related protein R Ras2; Related RAS viral (r ras) oncogene homolog 2; Related RAS viral oncogene homolog 2; RRAS 2; TC 21; TC21; Teratocarcino
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRAS2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞浆 细胞膜
畸胎瘤癌基因RAS相关病毒抗体产品介绍：background: This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine. Tissue Specificity: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. 畸胎瘤癌基因RAS相关病毒抗体Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. Post-translational modifications: May be post-translationally modified by both palmitoylation and polyisoprenylation. DISEASE: Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs 畸胎瘤癌基因RAS相关病毒抗体and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Similarity: Belongs to the small GTPase superfamily. Ras family. Gene ID: 22800 Database links: Entrez Gene: 22800 Human Omim: 600098 Human SwissProt: P62070 Human Unigene: 502004 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
畸胎瘤癌基因RAS相关病毒抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid