OS-9蛋白抗体
规格：1mg/1ml
英文名： OS9
别名： lified in osteosarcoma 9; amplified in osteosarcoma; OS-9; Os9; OS9_HUMAN; Protein OS-9.
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OS9
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
OS-9蛋白抗体产品介绍：background: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Subunit: Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 andOS-9蛋白抗体 SEL1L with which it interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with HSP90B1 and CREB3. Subcellular Location: ndoplasmic reticulum lumen. Tissue Specificity: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform OS-9蛋白抗体detected in all cell types examined. Post-translational modifications: Intramolecular disulfide bonds. Isoform 1 and isoform 2 are N-glycosylated. Similarity: Belongs to the OS-9 family. Contains 1 PRKCSH domain. Database links: UniProtKB/Swiss-Prot: Q13438.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产OS-9蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 染色质和核信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid