丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体
规格：1mg/1ml
英文名： ST14
别名： Epithin; HAI; Matripase; Matriptase; Membrane type serine protease 1; Membrane type serine protease; Membrane-type serine protease 1; MT SP1; MT-SP1; MTSP 1; MTSP1; Prostamin; PRSS 14; PRSS14; Serine
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ST14/MTS
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞膜
丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体产品介绍：background: MTSP1 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by 丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体cleavage of synthetic substrates with Arg or Lys as the P1 site. Subunit: Interacts with CDCP1. May interact with TMEFF1. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). DISEASE: Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Similarity: Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 4 LDL-receptor class A 丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体domains. Contains 1 peptidase S1 domain. Database links: UniProtKB/Swiss-Prot: Q9Y5Y6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 激酶和磷酸酶 细胞骨架 细胞外基质 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid