磷酸化肿瘤坏死因子受体1相关死亡域蛋白抗体
规格：1mg/1ml
英文名： phospho-TRADD (Ser296)
别名： TNFRSF1A(phospho S296); TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tu
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse,
细胞定位：细胞浆
磷酸化肿瘤坏死因子受体1相关死亡域蛋白抗体产品介绍：background: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Function: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Subcellular Location: Cytoplasm > cytoskeleton. 磷酸化肿瘤坏死因子受体1相关死亡域蛋白抗体Tissue Specificity: Found in all examined tissues. Similarity: Contains 1 death domain. Database links: Entrez Gene: 8717 Human Entrez Gene: 71609 Mouse Entrez Gene: 246756 Rat Omim: 603500 Human SwissProt:磷酸化肿瘤坏死因子受体1相关死亡域蛋白抗体 Q15628 Human SwissProt: Q3U0V2 Mouse Unigene: 460996 Human Unigene: 264255 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRADD在凋亡信号传导中起重要作用，近年来多用于研究其在肿瘤中的作用，探讨TRADD在促细胞凋亡和促细胞存活的机制如何控制，将有利于我们了解肿瘤发病机理。
磷酸化肿瘤坏死因子受体1相关死亡域蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid