胱抑素B/半胱氨酸蛋白酶抑制剂B抗体
规格：1mg/1ml
英文名： Cystatin B
别名： CPI B; CPI-B; CST6; CSTB; Cystatin B; Cystatin-B; CYTB; EPM1; Liver thiol proteinase inhibitor; PME; STFB; CHROW21; CYTB_HUMAN; EPM1A; Stefin-B; ULD.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cystatin
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞核 细胞浆 分泌型蛋白
胱抑素B/半胱氨酸蛋白酶抑制剂B抗体产品介绍：background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008] Function: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Subcellular Location: Cytoplasm.胱抑素B/半胱氨酸蛋白酶抑制剂B抗体 Nucleus.Secreted. Tissue Specificity: Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. 胱抑素B/半胱氨酸蛋白酶抑制剂B抗体Post-translational modifications: Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor. Similarity: Belongs to the cystatin family. Database links: Entrez Gene: 1476 Human Entrez Gene: 13014 Mouse Entrez Gene: 25308 Rat Omim: 601145 Human SwissProt: P04080 Human SwissProt: Q76LA1 Human SwissProt: Q62426 Mouse SwissProt: P01041 Rat Unigene: 695 Human Unigene: 6095 Mouse Unigene: 1233 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胱抑素B/半胱氨酸蛋白酶抑制剂B抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid