微丝相关蛋白hHBrk1抗体
规格：1mg/1ml
英文名： hHBrk1
别名： Brk1-like; C3orf10 chromosome 3 open reading frame 10; C3ORF10 GENE; Chromosome 3 open reading frame 10; hHBrk1; HSPC300; MDS027; Probable protein BRICK1; BRK1_HUMAN.
分子量： 8.7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human hHBrk1
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞浆
微丝相关蛋白hHBrk1抗体产品介绍：background: HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by微丝相关蛋白hHBrk1抗体 motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression. Function: Involved in regulation of actin and microtubuleorganization. Part of a WAVE complex that activates the Arp2/3complex. Subunit: Homotrimer when in free form. Directly interacts withWASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 orCYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex,微丝相关蛋白hHBrk1抗体 aheterdimer containing NCKAP1 and CYFIP1 interacts with aheterotrimer formed by WAVE1, ABI2 and BRK1. Subcellular Location: Cytoplasm, cytoskeleton Similarity: Belongs to the BRK1 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. hHBrkl可能参与调控肿瘤细胞迁移能力。
微丝相关蛋白hHBrk1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid