溶血磷脂酸?；泼甫驴固?/strong>
规格：1mg/1ml
英文名： Agpat2
别名： LPAAB; BSCL; BSCL1; EC 2.3.1.51; LPAAB; LPAAT beta; Lysophosphatidic acid acyltransferase beta; 1 acyl sn glycerol 3 phosphate acyltransferase beta; 1 acylglycerol 3 phosphate O acyltransferase 2; 1 A
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
溶血磷脂酸?；泼甫驴固?/strong>**原：KLH conjugated synthetic peptide derived from human LPAAB
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞膜
产品介绍：background: Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. It is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Expressed predominantly in heart and溶血磷脂酸酰基转移酶β抗体 liver. DISEASE: Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1) [MIM:608594]; also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of溶血磷脂酸?；泼甫驴固?/strong> diabetes. Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. Gene ID: 10555 Database links: Entrez Gene: 10555 Human Entrez Gene: 67512 Mouse Entrez Gene: 311821 Rat Omim: 603100 Human SwissProt: O15120 Human SwissProt: Q8K3K7 Mouse Unigene: 320151 Human Unigene: 24244 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
溶血磷脂酸?；泼甫驴固?/strong>产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid