?；窤硫酯酶8
规格：1mg/1ml
英文名： ACOT8
别名： ACTEIII; Acot8; ACOT8_HUMAN; acyl CoA thioesterase 8; Acyl-CoA thioesterase 8; Acyl-coenzyme A thioesterase 8; Choloyl coenzyme A thioesterase; Choloyl-coenzyme A thioesterase; hACTE III; hACTE-III; h
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ACOT8
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞浆
酰基辅酶A硫酯酶8产品介绍：background: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A Thioesterase 8, also known as ACOT8 may mediate Nef-induced down-regulation of CD4. It is a major thioesterase in peroxisomes and competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). It shows a preference for medium-length fatty acyl-CoAs and may be involved in the metabolic regulation of peroxisome proliferation. Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4.?；窤硫酯酶8 Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. Subunit: Interacts with HIV-1 Nef. Subcellular Location: Peroxisome. Tissue Specificity: Detected in a T-cell line (at protein level). Ubiquitous. Similarity: Belongs to the C/M/P thioester hydrolase family. Gene ID: 10005 Database links: Entrez Gene: 10005 ?；窤硫酯酶8Human Entrez Gene: 170789 Mouse Entrez Gene: 170588 Rat GenBank: NM_005469.3 Human Omim: 608123 Human SwissProt: O14734 Human SwissProt: P58137 Mouse SwissProt: Q8VHK0 Rat Unigene: 444776 Human Unigene: 277878 Mouse Unigene: 161868 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
?；窤硫酯酶8产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 **及病毒 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid