CUE结构域蛋白2抗体
规格：1mg/1ml
英文名： CUEDC2
别名： bA18I14.5; C10orf66; Chromosome 10 open reading frame 66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUED2_HUMAN; Cuedc2; MGC2491; OTTHUMP00000020368.
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CUE doma
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
CUE结构域蛋白2抗体产品介绍：background: Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Subunit: Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues CUE结构域蛋白2抗体(at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. DISEASE: Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Similarity: Belongs to the CUEDC2 family. Contains 1 CUE domain. Database links: Entrez Gene: 79004 Human Entrez Gene: 67116 Mouse Entrez Gene: 294009 Rat Omim: 614142 Human SwissProt:CUE结构域蛋白2抗体 Q9H467 Human SwissProt: Q9CXX9 Mouse SwissProt: A1L131 Rat Unigene: 500874 Human Unigene: 218848 Mouse Unigene: 19673 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CUEDC2(CUE Domain Containing 2)能够结合IKKα和IKKβ,并通过使IKKα和IKKβ去磷酸化而抑制NF-κ信号通路。CUEDC2能特异性结合雌**受体（ER），并导致ER的泛素化降解.抑制乳腺癌细胞的生长。
CUE结构域蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 染色质和核信号 信号转导 激酶和磷酸酶 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid