肿瘤坏死因子α转换酶
规格：1mg/1ml
英文名： ADAM17
别名： A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha con
分子量： 68/93kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADAM17
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞膜
肿瘤坏死因子α转换酶产品介绍：background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]. Subunit: Interacts with MAD2L1, MAPK14 and MUC1. Subcellular Location: Membrane. Tissue Specificity: Ubiquitously expressed. Expressed at highest levels in ***** heart, placenta, skeletal muscle,肿瘤坏死因子α转换酶 pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Gene ID: 6868 Database links: Entrez Gene: 6868 Human Entrez 肿瘤坏死因子α转换酶Gene: 11491 Mouse Entrez Gene: 57027 Rat Omim: 603639 Human SwissProt: P78536 Human SwissProt: Q9Z0F8 Mouse SwissProt: Q9Z1K9 Rat Unigene: 404914 Human Unigene: 27681 Mouse Unigene: 144585 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子α转换酶产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid