鞘磷脂合成酶1抗体
规格：1mg/1ml
英文名： Sphingomyelin Synthase 1
别名： MOB; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; SGMS1; SMS 1; SMS1; TMEM23; Transmembrane protein 23; HSD36; SMS1_HUMAN; MOB.
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Sphingom
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
鞘磷脂合成酶1抗体产品介绍：background: Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]. Function: Sphingomyelin synthases synthesize the sphingolipid,sphingomyelin, through transfer of the phosphatidyl head group,phosphatidylcholine, on to the primary hydroxyl of ceramide. Thereaction is bidirectional depending on the respective levels of thesphingolipid and ceramide. Golgi apparatus SMS1 directly andspecifically recognizes the choline head group on the substrate,requiring two fatty chains on the choline-P donor molecule in orderto鞘磷脂合成酶1抗体 be recognized efficiently as a substrate. Major form inmacrophages. Required for cell growth in certain cell types such asHeLa cells. Suppresses BAX-mediated apoptosis and also preventscell death in response to stimuli such as hydrogen peroxide,osmotic stress, elevated temperature and exogenously suppliedsphingolipids. May protect against cell death by reversing thestress-inducible increase in levels of proapoptotic ceramide. Subcellular Location: Golgi apparatus membrane; Multi-passmembrane protein.[ALTERNATIVE PRODUCTS] Event=Alternative splicing;鞘磷脂合成酶1抗体 Namedisoforms=2; Name=1; IsoId=Q86VZ5-1; Sequence=Displayed; Name=2;IsoId=Q86VZ5-2; Sequence=VSP_027223, VSP_027224. Tissue Specificity: Brain, heart, kidney, liver, muscle andstomach. Similarity: Belongs to the sphingomyelin synthase family. Contains 1 SAM (sterile alpha motif) domain. Database links: UniProtKB/Swiss-Prot: Q86VZ5.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鞘磷脂合成酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid