受磷蛋白/心脏磷蛋白抗体
规格：1mg/1ml
英文名： phospholamban
别名： Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.
分子量： 5.7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human phosphol
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞浆 细胞膜 线粒体
受磷蛋白/心脏磷蛋白抗体产品介绍：background: The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation. Function: Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. Subcellular Location: Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum. Tissue Specificity: Heart. Post-translational modifications: Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes. DISEASE: Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder 受磷蛋白/心脏磷蛋白抗体characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of familial hypertrophic cardiomyopathy type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Similarity: Belongs to the受磷蛋白/心脏磷蛋白抗体 phospholamban family. Gene ID: 5350 Database links: Entrez Gene: 5350 Human Entrez Gene: 18821 Mouse Entrez Gene: 64672 Rat Omim: 172405 Human SwissProt: P26677 Chicken SwissProt: A4IFH6 Cow SwissProt: P61012 Dog SwissProt: P26678 Human SwissProt: P61014 Mouse SwissProt: P61013 Pig SwissProt: P61015 Rabbit SwissProt: P61016 Rat Unigene: 170839 Human Unigene: 34145 Mouse Unigene: 9740 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
受磷蛋白/心脏磷蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 信号转导 通道蛋白 线粒体 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid