磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体
规格：1mg/1ml
英文名： phospho-PFKL /PFK1(Ser775)
别名： PFKL (phospho S775); PFKL (phospho Ser775); p-PFKL (Ser775); ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; PFK-L; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Pho
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体产品介绍：background: Phosphofructokinases (PFKs) are regulatory glycolytic enzymes that catalyze the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Mammalian PFK is a tetramer made up of diverse combinations of three isoenzymes: muscle (PFK-1), liver (PFKL) and platelet (PFKP). PFKL (phosphofructokinase, liver), also referred to as PFK-B (Phosphofructo-1-kinase isozyme B), phosphofructokinase 1 or phosphohexokinase, predominates in organs with active gluconeogenesis, such as liver and kidney. Overexpression of PFKL in transgenic mice results in a diminished glucose-induced insulin response, which suggests that PFKL may play a role in glucose-induced insulin secretion. PFKL is expressed at high levels in Down's syndrome (DS) patients, suggesting a possible role for PFKL in the pathogenesis of DS. Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP. Subunit: Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. Subcellular Location:磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体 Cytoplasmic Post-translational modifications: GlcNAcylation decreases enzyme activity (By similarity). DISEASE: Defects in PFKM are the cause of glycogen storage disease type 7 (GSD7) [MIM:232800]; also known as Tarui disease. GSD7 is an autosomal recessive disorder characterized by exercise intolerance with associated nausea and vomiting. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise. Most patients obtain a 'second wind' when the onset of 磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体exercise is followed by a brief rest period. In time patients adjust their activity level and are well compensated. Similarity: Belongs to the phosphofructokinase family. Two domains subfamily. Database links: UniProtKB/Swiss-Prot: P08237.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid