12脂氧合酶抗体
规格：1mg/1ml
英文名： ALOX12
别名： 12 Lox; 12(S) lipoxygenase; 12S LOX; Alox 12; Alox12; Alox12L; Alox15; Arachidonate 12 lipoxygenase 12S type; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase leukocyte type; Arachidonate 12
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human 12 Lipox
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞浆
12脂氧合酶抗体产品介绍：background: 12 Lipoxygenase is a non heme iron containing dioxygenase which stereospecifically incorporates molecular oxygen into cis,cis-1,4-pentadiene containing polyunsaturated fatty acids. Murine leukocyte 12 Lipoxygenase oxidizes arachidonic acid to 12(S)-HpETE and 15(S)-HpETE in a ratio of 3:1. Murine leukocyte 12 Lipoxygenase is a 75 kDa protein which is 58% homologous to murine platelet 12 Lipoxygenase, and 70% homologous to porcine leukocyte 12 Lipoxygenase. Function: Converts arachidonic acid to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in B-cells, hair follicles, foreskin keratinocytes and ***** skin. Also expressed in psoriatic tissue. DISEASE: Defects in ALOX12B are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most12脂氧合酶抗体 affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery,12脂氧合酶抗体 and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Gene ID: 239 Database links: Entrez Gene: 242 Human Omim: 603741 Human SwissProt: O75342 Human Unigene: 136574 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
12脂氧合酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 转录调节因子 激酶和磷酸酶 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid