蛋白酪氨酸激酶BAP135抗体
规格：1mg/1ml
英文名： BAP135/TFII I
别名： BAP 135; BAP135; Bruton tyrosine kinase associated protein 135; BTK associated protein 135; BTK associated protein 135kD; BTK associated protein; BTKAP 1; BTKAP1; DIWS; General transcription factor II
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BAP135/T
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
蛋白酪氨酸激酶BAP135抗体细胞定位：细胞核 细胞浆
产品介绍：background: TFII I is a ubiquitously expressed multifunctional transcription factor with broad biological roles in transcription and signal transduction in a variety of cell types. It has been shown that TFII I can interact physically and functionally with Btk (Bruton's tyrosine kinase), a hematopoietic non-receptor protein tyrosine kinase that is critical for B lymphocyte development. Function: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Subcellular Location: Cytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm. Tissue Specificity: Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in ***** brain, 蛋白酪氨酸激酶BAP135抗体muscle, and lymphoblasts and is almost undetectable in other ***** tissues, while the other isoforms are equally expressed in all ***** tissues. Post-translational modifications: Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. Sumoylated. DISEASE: Note=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.蛋白酪氨酸激酶BAP135抗体 Similarity: Belongs to the TFII-I family. Contains 6 GTF2I-like repeats. Gene ID: 2968 Database links: Entrez Gene: 2969 Human Entrez Gene: 14886 Mouse Entrez Gene: 353256 Rat Omim: 601679 Human SwissProt: P78347 Human SwissProt: Q9ESZ8 Mouse SwissProt: Q5U2Y1 Rat Unigene: 647041 Human Unigene: 261570 Mouse Unigene: 412191 Mouse Unigene: 27575 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸激酶BAP135抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid