神经细胞胞浆蛋白9.5抗体
规格：1mg/1ml
英文名： PGP9.5
别名： Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Park5; Parkinson Disease 5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal h
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PGP95
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig, G
细胞定位：细胞浆 细胞膜
神经细胞胞浆蛋白9.5抗体产品介绍：background: catalyzes the hydrolysis of ubiquitin carboxy-terminal thiolesters to form ubiquitin and a thiol; may play a role in neuropathic pain [RGD]. Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Subcellular Location: Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain. Tissue Specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Post-translational modifications: O-glycosylated. DISEASE: Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:613643]; also known as神经细胞胞浆蛋白9.5抗体 Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Similarity: Belongs to the peptidase C12 family. Database links: Entrez Gene: 7345 Human Entrez Gene: 22223 Mouse Entrez Gene: 396637 Pig Entrez Gene: 29545神经细胞胞浆蛋白9.5抗体 Rat Entrez Gene: 101117250 Sheep Entrez Gene: 325119 Zebrafish Omim: 191342 Human SwissProt: P09936 Human SwissProt: Q9R0P9 Mouse SwissProt: Q6SEG5 Pig SwissProt: Q00981 Rat Unigene: 518731 Human Unigene: 29807 Mouse Unigene: 107213 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 该抗原是一种神经特异性蛋白，广泛分布于**与外周神经系统的神经元和神经纤维、神经***细胞、肾小管段、睾丸精原细胞、Leydig细胞、卵细胞以及妊娠与非妊娠黄体内的某些细胞。用于标记神经元，对研究几种人慢性神经变性性**中广泛存在的细胞包涵神经细胞胞浆蛋白9.5抗体体特征较有意义。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid