胆固醇酯转移蛋白抗体
规格：1mg/1ml
英文名： CETP
别名： BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfe
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CETP
交叉反应：Human,
胆固醇酯转移蛋白抗体细胞定位：细胞外基质 分泌型蛋白
产品介绍：background: High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In 胆固醇酯转移蛋白抗体general elevated levels of CETP have been associated with increased risk of coronary heart disease. Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP 胆固醇酯转移蛋白抗体family. Database links: Entrez Gene: 1071 Human Omim: 118470 Human SwissProt: P11597 Human SwissProt: P22687 Rabbit Unigene: 89538 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CETP系一疏水糖蛋白，胆固醇酯转运蛋白--介导HDL中的胆固醇与VLDL中的甘油三酯等交换，促进HDL中的胆固醇净转运，可促进胆固醇酯在细胞与血浆脂蛋白间的转运，参与胆固醇的逆转运过程。
胆固醇酯转移蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 脂蛋白 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid